Endocrine Abstracts

Context: Little research has been performed on hemostatic changes in transgender subjects receiving cross-sex hormone treatment (CSHT), despite the fact that several studies implicate an increased risk of venous thrombosis (VT) associated with hormones.Objective: Assessing whether coagulation is relevantly influenced by prolonged CSHT, stratified for the different treatment modalities, in transgenders.Design and main outcome: Prosp...

Background: Bone marrow fat is a unique fat depot that is regulated independently of other fat depots. Estradiol is an important regulator of bone marrow fat. This is illustrated by an increase in marrow fat fraction after menopause and a decrease following estradiol replacement. We hypothesize that estradiol is the major sex steroid that regulates bone marrow fat not only in women, but also in men.Methods: This is an open-label partly randomized interve...

Background: The effect of testosterone on sexual arousal has been described in testosterone withdrawal and re-adminstration studies in birth-assigned males. In birth-assigned females, the relationship between sex steroids and sexual arousal is complex. Several steps in the transitioning process may affect sexual desire: hormone therapy (HT) and gender affirming surgery. HT in transgender men (TM) generally leads to increased sexual desire, masturbation frequency, sexual fantas...

Introduction: Cross-sex hormone therapy is part of the treatment of individuals with gender dysphoria and affects several factors such as body composition and thereby cardiovascular risk. However, little is known about the specific effects on body weight and fat percentage in the first year of treatment.Aim: The aim of this study is to examine the effects of cross-sex hormones on body weight and total fat percentage during the first year of treatment.</p...

Introduction: Anger is an emotional state of feelings varying from mild irritation to intense rage, whereas aggression implies externalizing angry emotions through destructive/ punitive behavior towards other persons/objects. Although research on the relationship between testosterone and aggression is inconclusive, the WPATH SOC 7 guidelines have warned for an increase in aggression in transgender men (TM) taking testosterone treatment.Aims:<p class=...

Introduction: Testosterone is known to have an effect on hematocrit levels, with polycythemia as an unwanted side effect. An increase in hematocrit levels is also seen in transmen after starting cross-sex hormonal treatment (CHT) with testosterone. The aim of this study is to investigate the effect of cross-sex hormonal treatment with testosterone on hematocrit levels in the context of the safety aspects of this treatment. The prevalence, determinants and outcome of secondary ...